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What's more, at unique concentrations, triptolide was uncovered to induce the phosphorylation of p53 for the serine-15 residue in HepG2 cells. Activating the tumor suppressor gene p53 can induce the apoptosis of liver cancer cells 36.The pentacyclic triterpenoid celastrol has been discovered as An important bioactive metabolite of T. wilfordiigenes